(informal)it is the end or there is no hope for (someone or something)
(非正式)对…，一切都完了
(Brit.)steadily improving or becoming more successful
(英)稳步提高
(chiefly N. Amer.)honest or sincere
(主北美)诚实的，正直的
(informal)something unusual or undesirable is happening or afoot
(非正式)不寻常（或不好）的事发生了
(informal)facing some serious but unspecified difficulty
(非正式)面对某种困难，面临某种困境
they play better when they're up against it.
面对困难时，他们打得更好。
no longer in bed (after sleep or an illness)
（睡眠或生病后） 起床；下床
active; busy
忙碌的，积极肯干的
a normal young chap wants to be up and doing.
正常的年轻人总想积极向上。
moving upwards and downwards
一上一下，起伏
bouncing up and down.
上下跳动。
to and fro
来来回回，往返地
pacing up and down in front of her desk.
在她书桌前踱来踱去。
in various places throughout
到处，处处
in clubs up and down the country.
在全国各地俱乐部。
(informal)in varying states or moods; changeable
(非正式)（情绪，状态）多变的
my relationship with her was up and down.
我和她的关系变化不定。
(especially of a computer system) in operation; functioning
（尤指计算机系统）运行中
the new computer is up and running.
新电脑在运行。
the new computer is up and running.
新电脑在运行。
appearing for a hearing in the presence of
出庭面对
we'll have to come up before a magistrate.
我们将不得不出庭面对治安法官。
available for
正待
the house next door is up for sale.
隔壁房子正待出售。
being considered for
被考虑
he had been up for promotion.
他被考虑提升。
due for
到期
his contract is up for renewal in June.
他的合同将在六月到期续签。
(informal)ready to take part in (a particular activity)
(非正式)准备参加
Nigel was really &B{up for it}, as always.
像平常一样，奈吉尔真准备好参加了。
all over the place
到处
he led me up hill and down dale till my feet were dropping off.
他领着我到处走，直到我的腿都快断了。
(Brit. informal)in the brain (with reference to intelligence)
(英，非正式)头脑里（指智力）
a man with nothing much up top.
大脑空空的人。